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Skin changes typically take 4 to 12 weeks

Insulin resistance improves as reflected by lower fasting insulin and improved HOMA-IR

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In fact, a prior study demonstrated that children residing in konzo-prone regions of the DRC had a collective micronutrient deficiency that trended with disease severity, but such deficiencies are commonplace in populations across sub-Saharan Africa including those with low incidence of konzo 18

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Sigma-1 receptors modulate NMDA-mediated responses (262, 263)