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Additionally, vitamin B12 is necessary for the metabolism of cells throughout the body, including those involved in energy production and DNA synthesis

In line with this notion, conditional deletion of Ap2 in PGCs after specification using Blimp1-Cre resulted in severe germ cell depletion, with only a few residual PGCs detectable at E9.5 and complete loss of PGCs by E12.5 (Supplementary information, Fig

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