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Research from SURMOUNT-4 demonstrated that participants who continued tirzepatide at their achieved dose experienced an additional 5.5% weight reduction over 52 weeks, while those switched to placebo regained 14% of lost weight
The novel object recognition memory: neurobiology, test procedure, and its modifications
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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
Ard J, Fitch A, Fruh S, Herman L
(2025) T2DM: 46.5% discontinued by 1 year 64.1% discontinued by 2 years Without T2DM: 64.8% discontinued by 1 year 84.4% discontinued by 2 years Key Factors Linked to Discontinuation: Higher rates among patients without T2DM Age 65 years More likely to discontinue Higher weight loss during treatment Associated with lower discontinuation rates Moderate to severe GI side effects Higher likelihood of stopping treatment Higher income (T2DM only) Lower discontinuation rates Reinitiation of GLP-1: Source: Rodriguez PJ, Zhang V, Gratzl S, et al
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