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How safety data affects the approval timeline The dysesthesia signal will not necessarily prevent approval, but it will shape the labeling and potentially the approved dose range
These include Alzheimers Disease where neuroprotective effects are under investigation followed by stroke under similar notion (125) Futhermore, in non-alcoholic fatty liver disease (NAFLD) they show evidence of improved liver histology and hepatic steatosis (126) in PCOS they may help in regulation of weight, reproductive and metabolic parameters simultaneously (127) GLP1-Ras are also under study with their ability to modulate the hemodynamic and inflammatory pathways to treat CKD (128) and Heart failure (129)
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Semaglutide diarrhea usually improves within a few days as the body adjusts, though timing varies
& Von Stedingk, L
