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Evidence Summaries and Recommendations From the International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome: Lifestyle Management

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Physiological melanin hyperpigmentation is the result of increased melanin biosynthesis by melanocytes in the basal cell layer of the oral epithelium, but pathological melanin pigmentation may be the result of increased number of normal melanocytes or atypical melanocytes, of increased melanogenic activity of normal or atypical melanocytes, or of both

Notify them if you observe significant changes in energy or if fatigue interferes with daily activities