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Although mitochondria do not play important roles in RSL3-induced ferroptosis, the evidence suggests that the mitochondrial ETC is indispensable for erastin-induced or cystine deprivation-mediated ferroptosis

Seppnen K, Kantola M, Laatikainen R, et al

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2 When a vitamin is taken by mouth, it has to make it through stomach acid, the gut wall, and a first pass through the liver before any of it reaches the bloodstream

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