what receptors does tirzepatide work on Tirzepatide: A Breakthrough Approach to Losing Weight Safely Tirzepatide * Mechanism of action:

Psychiatry 66, 6372

Typical pricing at 10 mg/mL concentration: 30 mg vial (12 weekly 2.5 mg doses): $180-360 = $15-30 per dose 50 mg vial (20 weekly 2.5 mg doses): $280-480 = $14-24 per dose 100 mg vial (40 weekly 2.5 mg doses): $480-800 = $12-20 per dose At 5 mg/mL concentration (less common), the same 2.5 mg dose requires 50 units (0.5 mL), so vials deplete faster: 30 mg vial (12 doses): same $180-360 range Cost per dose: $15-30 At 20 mg/mL concentration (higher-dose optimization), 2.5 mg requires only 12.5 units (0.125 mL): 30 mg vial yields 12 doses at 2.5 mg each 60 mg vial yields 24 doses Cost per dose: $15-35 depending on pharmacy The per-dose cost of compounded tirzepatide is 95-98% lower than brand-name at the 2.5 mg starting dose

References Abi-Dargham A, Grace A

2014, 307, H1120-1133,

The difference between topical and injectable is not a marginal efficiency gain

The principal outcome - resolution of MASH in absence of fibrosis worsening - occurred in 40%, 36%, and 59% of individuals treated with semaglutide 0.1, 0.2, and 0.4 mg, respectively, vs