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Using co-immunoprecipitation (CO-IP), the study confirmed that FOXO4-DRI prevents FOXO4 binding to p53, facilitating phosphorylated p53 nuclear exclusion, which triggers BAX upregulation and cleaved caspase-3 activation driving selective apoptosis of senescent endothelial cells

Battistin L, Pizzolato G, Dam M, and et al

[updated 2023 Jul 30

retatrutides ~24.2% was measured at 48 weeks at 12 mg

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While this establishes general tolerability, the safety and efficacy of intra-articular administration for joint support requires specific clinical investigation