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In a phase 2 dose-finding trial, once-weekly Cagrilintide produced clinically meaningful weight loss about 10.8% at the 4.5 mg dose over 26 weeks with gastrointestinal effects the most common adverse events [1]

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Mechanism Inhibits NNMT enzyme activity Increases NAD+ levels in cells Promotes mitochondrial function and energy expenditure Reduces adiposity and improves glucose metabolism in animal models Research Applications Obesity and metabolic syndrome models Mitochondrial dysfunction studies NAD+ metabolism research Energy expenditure regulation Cagrilintide: Amylin Analog Research Applications What Is Cagrilintide