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However, it should be noted that this combination therapy strategy does not reverse the tumor-promoting effects of previous insulin treatments [42]

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Since Pycnogenol constituents and metabolites bound to blood cells, distribution into endothelial cells was additionally investigated ( in vitro setting, the binding of the microbial metabolite 5-(3,4-dihydroxyphenyl)--valerolactone to cells of the endothelial cell line EA.hy 926 was determined

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