Intervention studies highlight therapeutic potential: Lactobacillus johnsonii supplementation reduces immune cell activation in lungs and Th2 cytokine expression (IL-4, IL-5, IL-13, IL-17), suggesting microbiota-targeted strategies for AHR modulation (Aagaard et al., 2012)
In addition, enhanced plasma levels of pyroptosis markers were detected in COVID-19 patients, and the levels of caspase -1 and IL-18 in serum correlated with the degree of COVID-19 severity (220, 221), particularly in elderly patients (234)
187 RaithelMWeidenhillerMHagelAFKHetterichUNeurathMFKonturekPC
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Defining the mitochondrial signals linking CI respiration to transcription will be key to understanding how circadian clocks coordinate cellular identity with metabolic state
JNK activation is associated with intracellular beta-amyloid accumulation
