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In addition to losing fat, many people also lose valuable muscle mass
Aspects like your genetics, adherence to treatment, diet, and exercise play a role in the results you see

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Tretinoin addresses hyperpigmentation by increasing cell turnover, while glutathione helps by reducing oxidative stress and influencing the melanin pathway, potentially preventing new pigment from forming.
Excess oxidative activity may reduce the availability of nitric oxide, a molecule that helps blood vessels relax