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Epac activates the MAPK pathway, thereby promoting the activity of cyclin-dependent kinase 2 (CDK2) and CDK4, which in turn facilitate -cell differentiation and proliferation [35, 36] (Fig
Six-week-old male C57BL/6 mice and adult male Wistar rats (240260 g) were purchased from the Experimental Animal Center of the Shanxi Provincial Peoples Hospital (Taiyuan, China)
During training, the body first uses muscle glycogen for energy
It is distributed to every cell of the body upon binding to Transcobalamine II, a B-globulin carrier protein and is stored in the liver in an amount of 300- 500 microgram
Green et al., 2006
[1] [2] Renal and hepatic function may influence treatment outcomes
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