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Patients with a history of diabetic retinopathy should have baseline ophthalmology evaluation, as rapid glucose lowering may temporarily worsen vision

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This is why many clinicians keep patients at 10 mg

Cardiovascular Effects Blood Pressure and Circulation PT-141 is known to cause temporary spikes in blood pressure, which may be problematic for women with hypertension, migraines, or cardiovascular conditions

The protein "shares a high sequence homology to the active enzyme in rattlesnake venom and, like venom coursing through the body, it has the capacity to bind to receptors at neuromuscular junctions and potentially disable the function of these muscles," Chilton described