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Clinical trials show both drugs cause gastrointestinal symptoms, but tirzepatide's action on two hormone receptorsGLP-1 and GIPcreates a unique tolerability signature that differs from semaglutide's single-pathway approach

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Infatti, tali benefici non sono completamente spiegabili dal solo controllo glicemico, plausibile che la riduzione dellinfiammazione vascolare e dello stress ossidativo contribuisca al beneficio cardiovascolare globale [4,12]

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