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In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years
Patients may need to avoid strenuous activities and follow specific care instructions during healing
Billed monthly
Who should avoid it, warning signs to watch for, and what to know before combining it with other compounds
Coverage is more likely when: You have a diagnosed deficiency: blood work shows your B12 level is below the standard range
Eating a light meal before the injection and staying hydrated can help reduce nausea
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