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Regarding safety in real-world practice, these large observational studies have not identified unexpected safety signals beyond those known from clinical trials
doi: 10.1038/s41467-019-09101-4 118 LagaresDSantosAGrasbergerPELiuFProbstCKRahimiRAet al
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Other ingredients Rice flour, hypromellose (cellulose capsule), microcrystalline cellulose, stearic acid (vegetable source) and silicon dioxide
A aggregation and tau hyperphosphorylation can disrupt the calcium balance in neurons, leading to mitochondrial calcium overload, increased reactive oxygen species production, reduced ATP generation, and ultimately, neuronal apoptosis or necrosis [76, 77]
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