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In the PNS, thiamine deficiency can result in polyneuritis and paralysis, as seen in dry beriberi, which affects the sensory system, causing pain, altered temperature sensitivity, numbness, reduced tendon reflexes, and leg atrophy (6, 11, 36)

Eligible adults across New York may complete their evaluation through secure telehealth, with personalized treatment recommendations based on individual needs

Direct, continuous effects are not well established in humans

This guide breaks down every meaningful comparison between mazdutide and retatrutide, from molecular mechanisms to real trial data, so you can understand exactly how these two next-generation compounds stack up against each other and against the current standard treatments

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We do not provide usage or dosage guidance