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The 2022 New England Journal of Medicine study showing effectiveness of Wegovy at preventing Major Adverse Cardiovascular Events (MACE) required 100 people to be treated for 3 years to prevent one MACE event
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Given the current lack of robust evidence from long-term, large-sample RCTs, the majority of evidence for pharmacological interventions targeting MC4R -deficient obesity discussed in this review - particularly for liraglutide and semaglutide - derives from case reports
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