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Similar effects have been demonstrated in osteoarthritis models, where liraglutide facilitates macrophage polarization toward the anti-inflammatory M2 phenotype by downregulating M1-associated markers such as Mcp-1 and Cd38, while upregulating M2-related genes including Erg-2, reducing the secretion of pro-inflammatory cytokines and mitigates inflammatory responses (Meurot et al., 2022)

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However, over time, the pancreas may become exhausted and unable to keep up with the demand for insulin, leading to type 2 diabetes.Insulin resistance is also associated with other metabolic abnormalities, including high levels of triglycerides and low levels of HDL cholesterol, a condition known as dyslipidemia