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91.9% achieved 5% weight loss vs 31.5% placebo

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seek urgent medical advice for right upper quadrant pain or jaundice Diabetic retinopathy complications : Patients with pre-existing retinopathy should have regular ophthalmological monitoring, as rapid glycaemic improvement may temporarily worsen retinal disease Renal impairment : Dehydration from gastrointestinal side effects can affect kidney function, particularly in vulnerable patients Injection site reactions (redness, itching, bruising) are common but usually mild

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Indeed, the combination of a DPP-4 inhibitor with metformin provides substantial and additive glycaemic improvement compared with metformin alone in patients with type 2 diabetes [17, 18]

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Efinopegdutide administered once weekly at 10 mg produced a greater hepatic fat decrease than semaglutide 1 mg in patients with NAFLD (LS mean -72.7% vs

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