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The NIH's general framework for peptide pharmacokinetics confirms that hepatic contribution to small peptide clearance varies widely, from negligible to dominant, depending on lipophilicity and plasma protein binding
References: Wang C, Crapo LM (1997) The epidemiology of thyroid disease and implications for screening
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SAFETY AND EFFICACY CONCERNS RAISED BY THE FDA, AUSTRALIAN GOVERNMENT, AND BIG PHARMA AFTER FIVE DIE ON COMPOUNDED GLP-1 DRUGS, AND OTHERS REPORT SERIOUS SIDE EFFECTS Despite allowing compounding, the FDA has expressed concerns about GLP-1 knockoffs
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