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The American College of Cardiology recommends continuing baseline statin therapy, as GLP-1 receptor agonists provide complementary cardiovascular benefits rather than serving as statin substitutes

Starting our patients with semaglutide also allows us to evaluate how they respond to GLP-1 therapy alone before potentially introducing the additional GIP action with tirzepatide

Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, glucagon) not yet approved by the MHRA or EMA as of 2025

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These effects relate directly to growth hormone elevation and typically resolve with dose adjustment

Understanding your genetic predispositions in peptide pathways alongside clinical biomarkers (fasting glucose, HbA1c, lipid profile, thyroid function) can help frame discussions about formulation choice