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4 Discussion GLP-1 receptor agonists significantly improve important biomarkers of systemic inflammation and oxidative stress in patients with type 2 diabetes (T2D), according to this systematic review and meta-analysis of 40 randomized controlled trials with 6,029 individuals

Although some studies have found that GIP on its own can trigger weight gain, when combined with GLP-1 agonists, it has been found to have profound weight loss benefits

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Data from the ORION study, presented at the Obesity Medicine Associations 2026 annual conference, showed that oral semaglutide 25 mg was associated with significantly greater mean weight loss than orforglipron in a population-adjusted indirect treatment comparison