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The label recommends glucose monitoring and notes that tesamorelin should not be started in patients with active malignancy given theoretical IGF-1-mediated proliferation
CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis
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GLP-1s are off both lists
Drugs like Ozempic may be able to prevent further damage, partly because weight loss reduces the risk of hypertension and Type 2 diabetes, which are risk factors for chronic kidney disease
Safety and monitoring considerations for research applications include assessment of potential effects on tissue regeneration, immune function, and wound healing capacity, as senescent cells may play beneficial roles in some biological processes
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