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Retatrutide is an investigational triple agonist (GLP-1, GIP, glucagon) not yet approved by the MHRA or EMA

Topiramate, by contrast, is an anticonvulsant and mood-stabilizing medication originally developed for seizure control

Acute administration of a Y1-R agonist may also reduce the rate of insulin secretion by pancreatic -cells 3,22

There have been some recent studies on microneedles patches

Growth hormone plays a fundamental role in preserving lean tissue during caloric deficit

Male C57Bl/6 mice (Charles River, UK) were fed a 60% high fat diet (D12492, Research Diets, USA) for 3 months prior to the study to induce obesity and glucose intolerance