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doi: 10.4093/dmj.2015.39.5.363 45

Three key modifications optimize its pharmacokinetics: Aib substitution at position 2 resists DPP-4 cleavage C18 fatty diacid via a hydrophilic linker at Lys26 enables strong, non-covalent albumin binding Arg substitution at position 34 prevents fatty acid binding at the wrong site These modifications produce a half-life of approximately 165 hours (7 days), enabling true once-weekly pharmacokinetics without microsphere encapsulation, plus a daily oral formulation (Rybelsus) using the SNAC absorption enhancer

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This step is critical in identifying any imbalances that need to be addressed through therapy

But they are not expected to impact depression, anxiety, and other mental health conditions directly