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Published Phase 2 data shows: Dose Group Discontinuation Due to AE Placebo 0% 1 mg 2.9% 4 mg (escalated) 5.7% 8 mg (escalated) 5.0% 12 mg (escalated) 8.3% For context, discontinuation rates in semaglutide 2.4 mg trials (STEP program) were approximately 7%, and tirzepatide 15 mg trials (SURMOUNT) reported approximately 6-7%

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Early in her tirzepatide regimen, Arnold sometimes tried to eat the foods she used to enjoy

Reporting summary Further information on research design is available in the Nature Research Reporting Summary linked to this article

In September 2023 the FDA placed roughly 19 peptide substances into Category 2 of its interim 503A bulks list, meaning the agency had identified potential significant safety risks and compounding pharmacies could not use them

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