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However, there are no human trials linking vascular changes to pregnancy results
Cardiovascular safety data from published trials showed reductions in systolic blood pressure (ranging from 4.3 to 7.9 mmHg depending on dose) and diastolic blood pressure (2.3 to 4.6 mmHg reductions)
The clinical consequence is most significant for drugs with narrow therapeutic indices where a 20 to 40% reduction in Cmax translates to subtherapeutic exposure
Dallas, TX: BenBella Books (2016)
The absence of validated efficacy data means youre titrating based on subjective experience and hope, not on a known dose-response curve
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