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There was no significant difference between sitagliptin and placebo in body weight change

Candidates Ideal candidates for semaglutide are individuals who have been diagnosed with type 2 diabetes or who struggle with obesity

The thinking was that rapid, substantial weight loss might thin the bones and raise the risk of fractures, particularly in people who are already vulnerable, like postmenopausal women." Surprising new research on semaglutide and fracture risk New research presented at an Endocrine Society meeting in Chicago found that people with type 2 diabetes who took semaglutide not only experienced more weight loss than those taking other diabetes and weight-loss medications, including Trulicity, Contrave and Qsymia, but they also had a 15 percent lower risk of bone fractures

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dulaglutide (Trulicity) for the treatment of type 2 diabetes (7% of 2025 revenues)