Restablece la comunicacin celular normal y reduce la fibrosis, a la vez que promueve la remodelacin tisular sana
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Corresponding with the aforementioned analysis, in MAFLD rats treated with metformin, there was a notable increase in the expression of DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains, Methylaspartate ammonia-lyase, tRNA C32,U32 (ribose-2-O)-methylase TrmJ or a related methyltransferase, Predicted dienelactone hydrolase, Intracellular sulfur oxidation protein, DsrE/DsrF family, 23S rRNA U2552 (ribose-2-O)-methylase RlmE/FtsJ, and 3-oxoacyl-[acyl-carrier-protein] synthase III compared to normal rats and untreated MAFLD rats
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Indeed, ALT telomeres have a relaxed telomeric chromatin configuration (compared to telomerase positive and normal cells) making them more susceptible to DNA damage and telomere elongation through ALT (Lin et al 2021
