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One of the greatest challenges in DSIP research has been the inability to identify a specific receptor through which the peptide consistently exerts its effects

(4) Clinical combinations: BBR-silymarin co-administration significantly improves glycemic control (fasting glucose, HOMA-IR) and lipid profiles (TG, LDL) in diabetic patients, and decreases BMI, and the WHR in obesity patients versus BBR monotherapy [196]

This was followed by incubation with HRP-conjugated second antibody (1:1000 dilutions) at room temperature, and finally the protein bands were visualized using enhanced chemiluminescence (Vazyme)

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Food and Drug Administration (FDA) has given it "Generally Recognized as Safe" (GRAS) status for use in food products

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