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Intrastriatal injection of pre-formed mouse -synuclein fibrils into rats triggers -synuclein pathology and bilateral nigrostriatal degeneration

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A systematic review and meta-analysis of 14 randomized controlled trials demonstrated that L-Carnitine supplementation (1-3 g/day) significantly reduced muscle soreness at 24 hours (weighted mean difference: -6.39, p=0.001) and 48 hours post-exercise (weighted mean difference: -1.53, p=0.03) compared to placebo