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High-fat meals delay gastric emptying further, potentially compounding the medication's effect and worsening bloating

Interestingly, FOXA1 is downregulated in liver samples from humans and rats with simple steatosis 71 , probably as a feedback mechanism to reduce FAs uptake by FABP1

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Evidence: Investigational (Grade D) very limited human data, mainly preclinical References: peer-reviewed IGF-1 and growth-factor physiology literature