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Thus, the clinical benefits for the risk of heart failure and kidney outcomes, except albuminuria, are likely to be a strength of SGLT2is, whereas those for the risk of stroke are a strength of GLP-1RAs (Graphical Abstract)

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doi: 10.1002/iub.2046 129 VinuNavarroJHerrero-CerveraAGarca-CubasMAndrs-BlascoIMartnez-HervsSet al

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But its real promise emerged when it was paired with semaglutide producing results that neither drug could achieve alone