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The mechanism is not fully understood but it is believed that the increased intracellular glutathione levels and increased ROS 217 are closely coupled with the build-up of toxic lipid peroxides and consequent ferroptosis

sgGCLC-a reverse: 5-AAACTCGCTTCAGGTGAGTATGC-3

Glutathione and vitamin C provide antioxidant defence against oxidative stress

However, upon pathogen sensing (LPS-induced), this deliberate physical uncoupling restricts mitochondrial FA -oxidation, thereby forcing a metabolic shift away from oxidative phosphorylation and toward aerobic glycolysis