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For data analysis, the raw data were processed with DIA-NN (v.1.9.2
A 100mg vial reconstituted with 5mL produces 20mg/mL, while a 50mg vial with the same 5mL produces 10mg/mL meaning the same target dose corresponds to twice the volume in the smaller vial
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Furthermore, it may alter the transcript levels of genes involved in oogenesis, folliculogenesis, and embryonic development 12 and impair nuclear and cytoplasmic maturation events such as the translocation of cortical granules and cytoskeletal rearrangement 13 , which can eventually lead to apoptosis 14
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