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Additionally, further study of the effect of these systemic medications on retinal cells, retinal metabolism and clinical behavior of DME is warranted

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Table 1 summarizes subtypes of hemochromatosis, genes involved, and clinical manifestations Overall reduced hepcidin levels result in the upregulation of ferroportin expression on enterocytes, hepatocytes, and macrophages, leading to increased iron efflux into circulation

This severe metabolic inflexibility directly contributes to the debilitating phenomenon of post-exertional malaise (PEM), where patients experience a massive, multi-day crash in symptoms following minor physical or cognitive exertion, effectively trapping them in a cycle of energy debt