The TRIUMPH-4 trial of retatrutide involved 445 participants with obesity and knee osteoarthritis, with 84% having a body mass index of 35 and over (the criteria for severe obesity)
Eating too little may lead to fatigue, dizziness, constipation, headaches, poor workouts, hair shedding, or trouble meeting protein and micronutrient needs
Tirzepatide (Zepbound, Mounjaro) : discontinue at least 1 month before pregnancy per Canadian labeling
Am J Psychiatry 2020;177(12):1168-78 Wilding JPH et al
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But its important to know when to seek medical evaluation