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Rashes, Hives, and Other Skin Reactions from Ozempic Injection site reactions such as redness, bruising, or discomfort are the most common skin issues with Ozempic and occur in fewer than one percent of people in trials

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It acts at the GHRH receptor on pituitary somatotroph cells and has been studied for its role in stimulating endogenous growth hormone release and downstream IGF-1 production