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Emergency treatment: If there is a slight nasal itch, apply a cold compress bag to the bridge of the nose and press gently for 5 minutes

Upon recognizing and binding lipopolysaccharide (LPS), mouse caspase-11 or human caspase-4/5 proteolytically cleaves GSDMD, leading to plasma membrane rupture (164)

We also conducted in vitro studies by infecting isolated PBMCs with either M

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Moreover, adequate safety margins were observed in repeat-dose rat and monkey toxicology studies, which supported advancing PF-06882961 to human clinical studies