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The work also suggests that the GLP-1R uses the ER as a platform to reach and signal into many different cellular organelles, not just mitochondria

24,29 Through this receptor, GLP-1 leads to an increase of cAMP levels that thereafter activates protein kinase A (PKA)

Genetic factors affecting GLP-1 receptor sensitivity are an area of ongoing research but currently have limited clinical utility for routine care

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Results Despite heterogeneity in study designs and populations, a largely consistent association was found between GLP-1RA use and a reduced incidence of glaucoma