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Southeast Asian J Trop Med Public Health 47:11531159

The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B 12 status

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The formation of HSPs in ME/CFS individuals is reduced (302), and the responses of plasma HSP27 and HSP70 are delayed or lowered, while resting levels of plasma HSP70 are also decreased (303)

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Answer: Most protocols begin with an initial phase of roughly three to six months, with progress reassessed using IGF-1 levels and clinical response