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Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem

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Research Use Only : This product is sold strictly for research purposes and is not intended for human consumption, therapeutic use, or veterinary applications

Some protocols extend beyond eight weeks depending on the severity of the condition and the patients response

Published online July 31, 2025