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Celebrities and influencers began endorsing their efficacy, further fueling the hype
[PubMed] National Institutes of Health
clinician evaluation determines candidacy
Buyer Takeaway 10: The published evidence points toward a four-part musculoskeletal protection strategy during GLP-1 therapy: baseline DXA measurement, resistance training at least twice weekly, adequate protein at every meal, and appropriate calcium/vitamin D
This approach works especially well for medication-driven, protocol-heavy conditions where outcomes improve with consistent follow-up rather than episodic care
However, clinical trials and real-world evidence consistently show that weight reduction with GLP-1RAs is accompanied by decrease in lean body mass, raising concern in patients already predisposed to muscle wasting and underscoring the need for integrated management strategies
