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Step 1: Establish a Foundation for Endometriosis Support These foundational supplements address the most common underlying drivers of endometriosis and are often well-tolerated as a starting point: Omega-3 fatty acids to help reduce inflammatory prostaglandins and immune activation Magnesium (ideally glycinate) to support muscle relaxation, pain modulation, sleep, and nervous system regulation Probiotics to support gut health, estrogen clearance, and immune balance NAC to help with pain, endometrioma management, and inflammation A targeted multivitamin or hormone-support formula to address nutrient depletion and estrogen metabolism Starting here helps stabilize inflammation, support detoxification pathways, and reduce baseline symptom burden before adding more targeted interventions