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Several large RCTs have shown that liraglutide and semaglutide are significantly more effective than controls in reducing liver fat content or resolving NASH [20-22]
All three tirzepatide doses outperformed semaglutide 1mg for both HbA1c reduction and weight loss
George Egesi, APRN, DNP Monthly Tirzepatide : For your health Home Kit & Support : All in one Affordable Options :$97 or $108 / week Interest-free payments with Affirm
Besides the already discussed actions of IGF-1 on glucose, it also has an indirect glucose-lowering effect secondary to its ability in increasing FA oxidation in muscle (will be further discussed in detail within the IGF - 1 and lipid metabolism section)
Importantly, controlled human data are largely limited to short-term experimental studies
Semaglutide is the established gold standard with FDA approval, proven cardiovascular benefit, extensive clinical data, and multiple formulation options
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