At week 52 in PIONEER 10, the use of additional anti-diabetic use and rescue medication use was 6% to 18% and 2% to 17%, respectively, for patients in semaglutide treatment groups and 12% and 9%, respectively in the dulaglutide treatment group
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In a major clinical trial called STEP 8, researchers compared the two medications directly
Safety Profile in Research Contexts Gastrointestinal events (nausea, vomiting, diarrhea, constipation) remain the most common adverse effects, typically mild to moderate, dose-dependent, and often mitigated by gradual dose escalation starting at lower levels (e.g., 2 mg)
Lifestyle Changes: Semaglutide works best when combined with a healthy diet and regular exercise
The incretin hormone system evolved to coordinate metabolic responses to food intake