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In obese patients, the EAT secretes several pro-inflammatory chemokines and cytokines, collectively called adipokines such as tumor necrosis factor alpha (TNF-), monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), IL-1, plasminogen activator inhibitor-1 (PAI-1), resistin, S100A9, and many others (45)

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Similarly, Lin et al

Clinical pharmacokinetics and pharmacodynamics of albiglutide

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For peptides needing multiple draws, this is a major risk, as reconstituted solutions can degrade or become unusable fast