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Medication persistence adds another layer: Claims analyses suggest steep drop-off rates by years one and two, making initiation criteria and ongoing maintenance support an economic consideration as well as a clinical one
It reflects a genuinely novel mechanism that explains why the clinical outcomes have been so striking, not just for diabetes and weight loss, but potentially for conditions like PCOS where metabolic dysfunction drives the disease
Glucagon-like peptide-1 receptor (GLP-1R) belongs to the family B of G-protein coupled receptors (GPCR)
Preclinical studies have shown thyroid C-cell tumours in rodents, though the relevance to humans is uncertain
However, both studies favored tirzepatide over semaglutide
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